Strong Amerind/White Sex Bias and a Possible Sephardic Contribution among the Founders of a Population in Northwest Colombia
Identifieur interne : 001022 ( Main/Exploration ); précédent : 001021; suivant : 001023Strong Amerind/White Sex Bias and a Possible Sephardic Contribution among the Founders of a Population in Northwest Colombia
Auteurs : Luis G. Carvajal-Carmona [Colombie] ; Iván D. Soto [Colombie] ; Nicolás Pineda [Colombie] ; Daniel Ortíz-Barrientos [Colombie] ; Constanza Duque [Colombie] ; Jorge Ospina-Duque [Colombie] ; Mark Mccarthy [Royaume-Uni] ; Patricia Montoya [Colombie] ; Victor M. Alvarez [Colombie] ; Gabriel Bedoya [Colombie] ; Andrés Ruiz-Linares [Royaume-Uni, Colombie]Source :
- The American Journal of Human Genetics [ 0002-9297 ] ; 2000.
Abstract
Historical and genetic evidences suggest that the recently founded population of Antioquia (Colombia) is potentially useful for the genetic mapping of complex traits. This population was established in the 16th–17th centuries through the admixture of Amerinds, Europeans, and Africans and grew in relative isolation until the late 19th century. To examine the origin of the founders of Antioquia, we typed 11 markers on the nonrecombining portion of the Y chromosome and four markers on mtDNA in a sample of individuals with confirmed Antioquian ancestry. The polymorphisms on the Y chromosome (five biallelic markers and six microsatellites) allow an approximation to the origin of founder men, and those on mtDNA identify the four major founder Native American lineages. These data indicate that ∼94% of the Y chromosomes are European, 5% are African, and 1% are Amerind. Y-chromosome data are consistent with an origin of founders predominantly in southern Spain but also suggest that a fraction came from northern Iberia and that some possibly had a Sephardic origin. In stark contrast with the Y-chromosome, ∼90% of the mtDNA gene pool of Antioquia is Amerind, with the frequency of the four Amerind founder lineages being closest to Native Americans currently living in the area. These results indicate a highly asymmetric pattern of mating in early Antioquia, involving mostly immigrant men and local native women. The discordance of our data with blood-group estimates of admixture suggests that the number of founder men was larger than that of women.
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DOI: 10.1016/S0002-9297(07)62956-5
Affiliations:
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This population was established in the 16th–17th centuries through the admixture of Amerinds, Europeans, and Africans and grew in relative isolation until the late 19th century. To examine the origin of the founders of Antioquia, we typed 11 markers on the nonrecombining portion of the Y chromosome and four markers on mtDNA in a sample of individuals with confirmed Antioquian ancestry. The polymorphisms on the Y chromosome (five biallelic markers and six microsatellites) allow an approximation to the origin of founder men, and those on mtDNA identify the four major founder Native American lineages. These data indicate that ∼94% of the Y chromosomes are European, 5% are African, and 1% are Amerind. Y-chromosome data are consistent with an origin of founders predominantly in southern Spain but also suggest that a fraction came from northern Iberia and that some possibly had a Sephardic origin. In stark contrast with the Y-chromosome, ∼90% of the mtDNA gene pool of Antioquia is Amerind, with the frequency of the four Amerind founder lineages being closest to Native Americans currently living in the area. These results indicate a highly asymmetric pattern of mating in early Antioquia, involving mostly immigrant men and local native women. The discordance of our data with blood-group estimates of admixture suggests that the number of founder men was larger than that of women.</div></front></TEI><affiliations><list><country><li>Colombie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Colombie"><noRegion><name sortKey="Carvajal Carmona, Luis G" sort="Carvajal Carmona, Luis G" uniqKey="Carvajal Carmona L" first="Luis G." last="Carvajal-Carmona">Luis G. Carvajal-Carmona</name></noRegion><name sortKey="Alvarez, Victor M" sort="Alvarez, Victor M" uniqKey="Alvarez V" first="Victor M." last="Alvarez">Victor M. Alvarez</name><name sortKey="Bedoya, Gabriel" sort="Bedoya, Gabriel" uniqKey="Bedoya G" first="Gabriel" last="Bedoya">Gabriel Bedoya</name><name sortKey="Duque, Constanza" sort="Duque, Constanza" uniqKey="Duque C" first="Constanza" last="Duque">Constanza Duque</name><name sortKey="Montoya, Patricia" sort="Montoya, Patricia" uniqKey="Montoya P" first="Patricia" last="Montoya">Patricia Montoya</name><name sortKey="Ortiz Barrientos, Daniel" sort="Ortiz Barrientos, Daniel" uniqKey="Ortiz Barrientos D" first="Daniel" last="Ortíz-Barrientos">Daniel Ortíz-Barrientos</name><name sortKey="Ospina Duque, Jorge" sort="Ospina Duque, Jorge" uniqKey="Ospina Duque J" first="Jorge" last="Ospina-Duque">Jorge Ospina-Duque</name><name sortKey="Pineda, Nicolas" sort="Pineda, Nicolas" uniqKey="Pineda N" first="Nicolás" last="Pineda">Nicolás Pineda</name><name sortKey="Ruiz Linares, Andres" sort="Ruiz Linares, Andres" uniqKey="Ruiz Linares A" first="Andrés" last="Ruiz-Linares">Andrés Ruiz-Linares</name><name sortKey="Soto, Ivan D" sort="Soto, Ivan D" uniqKey="Soto I" first="Iván D." last="Soto">Iván D. Soto</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mccarthy, Mark" sort="Mccarthy, Mark" uniqKey="Mccarthy M" first="Mark" last="Mccarthy">Mark Mccarthy</name></region><name sortKey="Ruiz Linares, Andres" sort="Ruiz Linares, Andres" uniqKey="Ruiz Linares A" first="Andrés" last="Ruiz-Linares">Andrés Ruiz-Linares</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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